Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3.
نویسندگان
چکیده
We report here the syntheses of mono- to tetravalent glycoclusters containing 1-methylene-C-β-lactose. The 1-methylene-C-β-lactose moiety has been synthesized from octa-acetyl-β-lactose using the key carbonyl insertion reaction and linked to a series of alkynlated scaffolds via CuAAC reaction to afford mono- to tetravalent glycoclusters. The binding affinities of the final products to galectin-3 were found in the range of 10-100 μM.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 41 شماره
صفحات -
تاریخ انتشار 2014